I-kappaB phosphorylation GO_0007252
I-kappaB phosphorylation
ID: GO_0007252
Class
The process of introducing a phosphate group into an inhibitor of kappa B (I-kappaB) protein. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing bound NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
Open in VFB 3D Browser →Classification
Relationships
- is part of: canonical NF-kappaB signal transduction
Alternative Names
| Synonym | Scope | Reference |
|---|---|---|
| inhibitor of NF-kappaB phosphorylation | exact synonym | bf |
| IKB phosphorylation | exact synonym | bf |
| IkappaB phosphorylation | exact synonym | bf |
| inhibitor of kappaB phosphorylation | exact synonym | bf |