JNK cascade GO_0007254
JNK cascade
ID: GO_0007254
Class
A MAPK cascade containing at least the JNK (MAPK8) MAP kinase. It starts with the activation of JUN3K (a MAPK3K), which activates JNKK a MAP2K), which in turn activates JNK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier. The JNK cascade is activated by stress signals, as well as by G protein-coupled receptors, growth factors, and cytokines, and results in cellular responses such as cell proliferation, cell differentiation, apoptosis and inflammation.
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Alternative Names
| Synonym | Scope | Reference |
|---|---|---|
| MAPK10 cascade | narrow synonym | add |
| MAPK9 cascade | narrow synonym | add |
| JNK2 cascade | narrow synonym | add |
| JNK1 cascade | narrow synonym | add |
| JNK3 cascade | narrow synonym | add |
| SAPK cascade | broad synonym | |
| stress-activated protein kinase cascade | broad synonym | |
| MAPK8 cascade | exact synonym | add |
| c-Jun N-terminal kinase cascade | exact synonym | 20811974 |