dorsal anterior lateral neuron of the protocerebrum [FBbt_00110034]
A neuron whose cell body is located in the adult dorsal anteriolateral protocerebrum (Xia et al., 2005), extending its dendrites mainly in the superior dorsofrontal protocerebrum. It projects its axons in three different regions: where the dendritic tree is located and in the dorsolateral and inferior dorsofrontal protocerebrum domains. It establishes synaptic contacts with the pioneer mushroom body alpha/beta neurons in a small dorsal frontal domain of the mushroom body calyx (Chen et al., 2012). There are two pairs of DAL neurons per hemisphere (Xia et al., 2005). These neurons are involved in the retrieval of long-term memories (Chen et al., 2012) and are synapsed to mushroom body medial lobe arborizing neuron 4 and mushroom body vertical lobe arborizing neuron 3, which are also involved in long-term memory processing (Wu et al., 2017). Pre-and postsynaptic sites were assessed by synaptotagmin or Dscam-GFP stainings, respectively. Synaptic input to the pioneer mushroom body alpha/beta neurons was visualized using GFP reconstitution across synaptic partners (GRASP). Function in the retrieval of long-term memory was assessed using an olfactory associative learning assay. Memory retrieval was impaired when neurotransmission was blocked using UAS-Ricin in the DAL neurons labelled with E0946-GAL4, G0338-GAL4 or G0431-GAL4. Note that DAL neurons are a subset of the neurons labeled by these GAL4 line lines, and so their identity was confirmed by immunostaining for DDC (FBgn0000422) (Chen et al., 2012). GRASP also used to show connectivity with MBON-alpha3 and MBON-beta'2mp (Wu et al., 2017).
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VFB Term Json
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