follicle stem cell [FBbt_00004903]

Stem cell from which the follicle cells that envelop the germline cyst derive. They develop from the larval follicle stem cell progenitors (Slaidina et al., 2020). There are two follicle stem cells in each germarium, located at opposite sides of the lateral wall of the germarium, in between regions 2a and 2b (Reilein et al., 2017). Can be identified by expression of zfh1, Fas3 and low expression of Wnt4 (Rust et al., 2020).

Open follicle stem cell in VFB

VFB Term Json

{
    "term": {
        "core": {
            "iri": "http://purl.obolibrary.org/obo/FBbt_00004903",
            "symbol": "",
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                "Cell",
                "Class"
            ],
            "short_form": "FBbt_00004903",
            "label": "follicle stem cell"
        },
        "description": [
            "Stem cell from which the follicle cells that envelop the germline cyst derive. They develop from the larval follicle stem cell progenitors (Slaidina et al., 2020). There are two follicle stem cells in each germarium, located at opposite sides of the lateral wall of the germarium, in between regions 2a and 2b (Reilein et al., 2017)."
        ],
        "comment": [
            "Can be identified by expression of zfh1, Fas3 and low expression of Wnt4 (Rust et al., 2020)."
        ]
    },
    "query": "Get JSON for Class",
    "version": "44725ae",
    "parents": [
        {
            "symbol": "",
            "iri": "http://purl.obolibrary.org/obo/FBbt_00006010",
            "types": [
                "Entity",
                "Anatomy",
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                "Class"
            ],
            "short_form": "FBbt_00006010",
            "label": "gonadal somatic stem cell"
        },
        {
            "symbol": "",
            "iri": "http://purl.obolibrary.org/obo/FBbt_00006030",
            "types": [
                "Entity",
                "Anatomy",
                "Cell",
                "Class"
            ],
            "short_form": "FBbt_00006030",
            "label": "somatic cell of ovariole"
        }
    ],
    "relationships": [
        {
            "relation": {
                "iri": "http://purl.obolibrary.org/obo/BFO_0000050",
                "label": "is part of",
                "type": "part_of"
            },
            "object": {
                "symbol": "",
                "iri": "http://purl.obolibrary.org/obo/FBbt_00004866",
                "types": [
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                    "Anatomy",
                    "Class"
                ],
                "short_form": "FBbt_00004866",
                "label": "germarium"
            }
        },
        {
            "relation": {
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                "label": "expresses",
                "type": "expresses"
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            "object": {
                "symbol": "",
                "iri": "http://flybase.org/reports/FBgn0004606",
                "types": [
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                "short_form": "FBgn0004606",
                "label": "zfh1"
            }
        },
        {
            "relation": {
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                "type": "expresses"
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            "object": {
                "symbol": "",
                "iri": "http://flybase.org/reports/FBgn0010453",
                "types": [
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                "short_form": "FBgn0010453",
                "label": "Wnt4"
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        },
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            "object": {
                "symbol": "",
                "iri": "http://flybase.org/reports/FBgn0000636",
                "types": [
                    "Entity",
                    "Class"
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                "short_form": "FBgn0000636",
                "label": "Fas3"
            }
        },
        {
            "relation": {
                "iri": "http://purl.obolibrary.org/obo/RO_0002202",
                "label": "develops from",
                "type": "develops_from"
            },
            "object": {
                "symbol": "",
                "iri": "http://purl.obolibrary.org/obo/FBbt_00048548",
                "types": [
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                    "Larva"
                ],
                "short_form": "FBbt_00048548",
                "label": "larval follicle stem cell progenitor"
            }
        }
    ],
    "xrefs": [],
    "anatomy_channel_image": [],
    "pub_syn": [
        {
            "synonym": {
                "scope": "has_exact_synonym",
                "label": "somatic stem cell",
                "type": ""
            },
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                    "short_form": "FBrf0202474",
                    "label": "Nystul and Spradling, 2007, Cell Stem Cell 1(3): 277--285"
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                "FlyBase": "",
                "PubMed": "18371362",
                "DOI": "10.1016/j.stem.2007.07.009"
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        },
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                "label": "FSC",
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                "DOI": "10.1126/science.1165678"
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        },
        {
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                "scope": "has_exact_synonym",
                "label": "epithelial follicle stem cell",
                "type": ""
            },
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        },
        {
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                "label": "SSC",
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            },
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                },
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                "DOI": ""
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        }
    ],
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        },
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                "short_form": "FBrf0209788",
                "label": "Nystul and Spradling, 2010, Genetics 184(2): 503--515"
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            "FlyBase": "",
            "PubMed": "19948890",
            "DOI": "10.1534/genetics.109.109538"
        },
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                "short_form": "FBrf0247148",
                "label": "Rust et al., 2020, Nat. Commun. 11(1): 5628"
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            "PubMed": "33159074",
            "DOI": "10.1038/s41467-020-19361-0"
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                "short_form": "FBrf0244767",
                "label": "Slaidina et al., 2020, Genes Dev. 34(3-4): 239--249"
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            "FlyBase": "",
            "PubMed": "31919193",
            "DOI": "10.1101/gad.330464.119"
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                "short_form": "FBrf0235409",
                "label": "Reilein et al., 2017, Nat. Cell Biol. 19(5): 433--444"
            },
            "FlyBase": "",
            "PubMed": "28414313",
            "DOI": "10.1038/ncb3505"
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                "short_form": "FBrf0084162",
                "label": "Margolis and Spradling, 1995, Development 121(11): 3797--3807"
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    ]
}