mushroom body output neuron 1 [FBbt_00100234]
A bilateral, glutamatergic neuron whose cell body is located on the superior neuropils, anterior to the pars intercerebralis of the adult brain (Tanaka et al., 2008; Aso et al., 2014). The cell body fiber travels ventrally towards the medial lobe, arborizing in the anterior layer of beta’ lobe slice 2 and the most medial segment of the gamma lobe (slice 5) (Tanaka et al., 2008). The main fiber then enters the opposite gamma lobe, arborizes in the beta’ lobe slice 2 and gamma lobe slice 5. The major axon projects ipsilaterally to the superior medial protocerebrum (SMP), whereas a very thin axon projects to the crepine and SMP in the other hemisphere. There is one neuron of this type per hemisphere (Aso et al., 2014; Li et al., 2020). These neurons have synaptic connections with protocerebral anterior medial (PAM) cluster neurons in the SMP and in the tip of the mushroom body horizontal lobe (Owald et al., 2015). It is involved in the retrieval of long term memory associated with water reward (Shyu et al., 2017) as well as medium and long term aversive memory (Bouzaiane et al., 2015). Synapsing with PAM neurons determined by GRASP (Owald et al., 2015).
Note
This page displays the raw VFB json record for this term. Please use the link below to open the term inside the Virtual Fly Brain viewerOpen mushroom body output neuron 1 in VFB
Example Images
VFB Term Json
{
"term": {
"core": {
"iri": "http://purl.obolibrary.org/obo/FBbt_00100234",
"symbol": "MBON01",
"types": [
"Entity",
"Adult",
"Anatomy",
"Cell",
"Class",
"Glutamatergic",
"Nervous_system",
"Neuron"
],
"short_form": "FBbt_00100234",
"label": "mushroom body output neuron 1"
},
"description": [
"A bilateral, glutamatergic neuron whose cell body is located on the superior neuropils, anterior to the pars intercerebralis of the adult brain (Tanaka et al., 2008; Aso et al., 2014). The cell body fiber travels ventrally towards the medial lobe, arborizing in the anterior layer of beta' lobe slice 2 and the most medial segment of the gamma lobe (slice 5) (Tanaka et al., 2008). The main fiber then enters the opposite gamma lobe, arborizes in the beta' lobe slice 2 and gamma lobe slice 5. The major axon projects ipsilaterally to the superior medial protocerebrum (SMP), whereas a very thin axon projects to the crepine and SMP in the other hemisphere. There is one neuron of this type per hemisphere (Aso et al., 2014; Li et al., 2020). These neurons have synaptic connections with protocerebral anterior medial (PAM) cluster neurons in the SMP and in the tip of the mushroom body horizontal lobe (Owald et al., 2015). It is involved in the retrieval of long term memory associated with water reward (Shyu et al., 2017) as well as medium and long term aversive memory (Bouzaiane et al., 2015)."
],
"comment": [
"Synapsing with PAM neurons determined by GRASP (Owald et al., 2015)."
]
},
"query": "Get JSON for Class",
"version": "44725ae",
"parents": [
{
"symbol": "",
"iri": "http://purl.obolibrary.org/obo/FBbt_00058208",
"types": [
"Entity",
"Adult",
"Anatomy",
"Cell",
"Class",
"Glutamatergic",
"Nervous_system",
"Neuron"
],
"short_form": "FBbt_00058208",
"label": "adult glutamatergic neuron"
},
{
"symbol": "",
"iri": "http://purl.obolibrary.org/obo/FBbt_00049843",
"types": [
"Entity",
"Adult",
"Anatomy",
"Cell",
"Class",
"Nervous_system",
"Neuron"
],
"short_form": "FBbt_00049843",
"label": "adult typical mushroom body output neuron"
}
],
"relationships": [
{
"relation": {
"iri": "http://purl.obolibrary.org/obo/RO_0000053",
"label": "bearer of",
"type": "bearer_of"
},
"object": {
"symbol": "",
"iri": "http://purl.obolibrary.org/obo/PATO_0000618",
"types": [
"Entity",
"Class"
],
"short_form": "PATO_0000618",
"label": "bilateral"
}
},
{
"relation": {
"iri": "http://purl.obolibrary.org/obo/RO_0002216",
"label": "capable_of_part_of",
"type": "capable_of_part_of"
},
"object": {
"symbol": "",
"iri": "http://purl.obolibrary.org/obo/GO_0072375",
"types": [
"Entity",
"Class"
],
"short_form": "GO_0072375",
"label": "medium-term memory"
}
},
{
"relation": {
"iri": "http://purl.obolibrary.org/obo/RO_0002216",
"label": "capable_of_part_of",
"type": "capable_of_part_of"
},
"object": {
"symbol": "",
"iri": "http://purl.obolibrary.org/obo/GO_0007616",
"types": [
"Entity",
"Class"
],
"short_form": "GO_0007616",
"label": "long-term memory"
}
},
{
"relation": {
"iri": "http://purl.obolibrary.org/obo/RO_0002100",
"label": "has soma location",
"type": "has_soma_location"
},
"object": {
"symbol": "",
"iri": "http://purl.obolibrary.org/obo/FBbt_00100308",
"types": [
"Entity",
"Adult",
"Anatomy",
"Class",
"Nervous_system"
],
"short_form": "FBbt_00100308",
"label": "adult superior brain cell body rind"
}
},
{
"relation": {
"iri": "http://purl.obolibrary.org/obo/RO_0013008",
"label": "receives synaptic input from neuron",
"type": "receives_synaptic_input_from_neuron"
},
"object": {
"symbol": "PAM",
"iri": "http://purl.obolibrary.org/obo/FBbt_00100214",
"types": [
"Entity",
"Adult",
"Anatomy",
"Cell",
"Class",
"Dopaminergic",
"Nervous_system",
"Neuron"
],
"short_form": "FBbt_00100214",
"label": "dopaminergic PAM neuron"
}
},
{
"relation": {
"iri": "http://purl.obolibrary.org/obo/RO_0013002",
"label": "receives synaptic input in region",
"type": "receives_synaptic_input_in_region"
},
"object": {
"symbol": "",
"iri": "http://purl.obolibrary.org/obo/FBbt_00100277",
"types": [
"Entity",
"Adult",
"Anatomy",
"Class",
"Nervous_system",
"Synaptic_neuropil",
"Synaptic_neuropil_subdomain"
],
"short_form": "FBbt_00100277",
"label": "mushroom body gamma lobe slice 5"
}
},
{
"relation": {
"iri": "http://purl.obolibrary.org/obo/RO_0013002",
"label": "receives synaptic input in region",
"type": "receives_synaptic_input_in_region"
},
"object": {
"symbol": "",
"iri": "http://purl.obolibrary.org/obo/FBbt_00047093",
"types": [
"Entity",
"Adult",
"Anatomy",
"Class",
"Nervous_system",
"Synaptic_neuropil",
"Synaptic_neuropil_subdomain"
],
"short_form": "FBbt_00047093",
"label": "mushroom body anterior layer of beta\\' lobe slice 2"
}
},
{
"relation": {
"iri": "http://purl.obolibrary.org/obo/RO_0013009",
"label": "sends_synaptic_output_to_cell",
"type": "sends_synaptic_output_to_cell"
},
"object": {
"symbol": "PAM",
"iri": "http://purl.obolibrary.org/obo/FBbt_00100214",
"types": [
"Entity",
"Adult",
"Anatomy",
"Cell",
"Class",
"Dopaminergic",
"Nervous_system",
"Neuron"
],
"short_form": "FBbt_00100214",
"label": "dopaminergic PAM neuron"
}
},
{
"relation": {
"iri": "http://purl.obolibrary.org/obo/RO_0013003",
"label": "sends_synaptic_output_to_region",
"type": "sends_synaptic_output_to_region"
},
"object": {
"symbol": "",
"iri": "http://purl.obolibrary.org/obo/FBbt_00045037",
"types": [
"Entity",
"Adult",
"Anatomy",
"Class",
"Nervous_system",
"Synaptic_neuropil",
"Synaptic_neuropil_domain"
],
"short_form": "FBbt_00045037",
"label": "adult crepine"
}
},
{
"relation": {
"iri": "http://purl.obolibrary.org/obo/RO_0013003",
"label": "sends_synaptic_output_to_region",
"type": "sends_synaptic_output_to_region"
},
"object": {
"symbol": "",
"iri": "http://purl.obolibrary.org/obo/FBbt_00007055",
"types": [
"Entity",
"Adult",
"Anatomy",
"Class",
"Nervous_system",
"Synaptic_neuropil",
"Synaptic_neuropil_domain"
],
"short_form": "FBbt_00007055",
"label": "superior medial protocerebrum"
}
}
],
"xrefs": [
{
"link_base": "https://flybrain-ndb.virtualflybrain.org/neuronrec-",
"site": {
"symbol": "",
"iri": "http://virtualflybrain.org/reports/FlyBrain_NDB",
"types": [
"Entity",
"Individual",
"Site"
],
"short_form": "FlyBrain_NDB",
"label": "FlyBrain NeuronDB"
},
"is_data_source": false,
"link_postfix": [
".html"
],
"icon": "http://flybrain-ndb.virtualflybrain.org/NDB_title260.gif",
"accession": "10459",
"link_text": "mushroom body output neuron 1 on FlyBrain NeuronDB",
"homepage": "https://flybrain-ndb.virtualflybrain.org"
}
],
"anatomy_channel_image": [
{
"anatomy": {
"symbol": "",
"iri": "http://virtualflybrain.org/reports/VFB_0010145c",
"types": [
"Entity",
"Adult",
"Anatomy",
"Cell",
"Glutamatergic",
"Individual",
"NBLAST",
"Nervous_system",
"Neuron",
"has_image",
"has_neuron_connectivity"
],
"short_form": "VFB_0010145c",
"label": "MBON-y5B'2a_L (FAFB:2699293)"
},
"channel_image": {
"image": {
"template_channel": {
"symbol": "",
"iri": "http://virtualflybrain.org/reports/VFBc_00101567",
"types": [
"Entity",
"Individual",
"Template"
],
"short_form": "VFBc_00101567",
"label": "JRC2018Unisex_c"
},
"index": [],
"template_anatomy": {
"symbol": "",
"iri": "http://virtualflybrain.org/reports/VFB_00101567",
"types": [
"Entity",
"Adult",
"Anatomy",
"Individual",
"Nervous_system",
"Template",
"has_image"
],
"short_form": "VFB_00101567",
"label": "JRC2018Unisex"
},
"image_folder": "http://www.virtualflybrain.org/data/VFB/i/0010/145c/VFB_00101567/"
},
"channel": {
"symbol": "",
"iri": "http://virtualflybrain.org/reports/VFBc_0010145c",
"types": [
"Entity",
"Individual"
],
"short_form": "VFBc_0010145c",
"label": "MBON-y5B'2a_L (FAFB:2699293)_c"
},
"imaging_technique": {
"symbol": "TEM",
"iri": "http://purl.obolibrary.org/obo/FBbi_00000258",
"types": [
"Entity",
"Class"
],
"short_form": "FBbi_00000258",
"label": "transmission electron microscopy (TEM)"
}
}
},
{
"anatomy": {
"symbol": "",
"iri": "http://virtualflybrain.org/reports/VFB_jrchk0e2",
"types": [
"Entity",
"Adult",
"Anatomy",
"Cell",
"Glutamatergic",
"Individual",
"NBLAST",
"Nervous_system",
"Neuron",
"has_image",
"has_neuron_connectivity",
"has_region_connectivity"
],
"short_form": "VFB_jrchk0e2",
"label": "MBON01(y5B\\'2a)_R (FlyEM-HB:612371421)"
},
"channel_image": {
"image": {
"template_channel": {
"symbol": "",
"iri": "http://virtualflybrain.org/reports/VFBc_00101384",
"types": [
"Entity",
"Individual",
"Template"
],
"short_form": "VFBc_00101384",
"label": "JRC_FlyEM_Hemibrain_c"
},
"index": [],
"template_anatomy": {
"symbol": "",
"iri": "http://virtualflybrain.org/reports/VFB_00101384",
"types": [
"Entity",
"Adult",
"Anatomy",
"Individual",
"Nervous_system",
"Template",
"has_image"
],
"short_form": "VFB_00101384",
"label": "JRC_FlyEM_Hemibrain"
},
"image_folder": "http://www.virtualflybrain.org/data/VFB/i/jrch/k0e2/VFB_00101384/"
},
"channel": {
"symbol": "",
"iri": "http://virtualflybrain.org/reports/VFBc_jrchk0e2",
"types": [
"Entity",
"Individual"
],
"short_form": "VFBc_jrchk0e2",
"label": "MBON01(y5B\\'2a)_R - 612371421_c"
},
"imaging_technique": {
"symbol": "FIB-SEM",
"iri": "http://purl.obolibrary.org/obo/FBbi_00050000",
"types": [
"Entity",
"Class"
],
"short_form": "FBbi_00050000",
"label": "focussed ion beam scanning electron microscopy (FIB-SEM)"
}
}
},
{
"anatomy": {
"symbol": "",
"iri": "http://virtualflybrain.org/reports/VFB_jrchk0e2",
"types": [
"Entity",
"Adult",
"Anatomy",
"Cell",
"Glutamatergic",
"Individual",
"NBLAST",
"Nervous_system",
"Neuron",
"has_image",
"has_neuron_connectivity",
"has_region_connectivity"
],
"short_form": "VFB_jrchk0e2",
"label": "MBON01(y5B\\'2a)_R (FlyEM-HB:612371421)"
},
"channel_image": {
"image": {
"template_channel": {
"symbol": "",
"iri": "http://virtualflybrain.org/reports/VFBc_00101567",
"types": [
"Entity",
"Individual",
"Template"
],
"short_form": "VFBc_00101567",
"label": "JRC2018Unisex_c"
},
"index": [],
"template_anatomy": {
"symbol": "",
"iri": "http://virtualflybrain.org/reports/VFB_00101567",
"types": [
"Entity",
"Adult",
"Anatomy",
"Individual",
"Nervous_system",
"Template",
"has_image"
],
"short_form": "VFB_00101567",
"label": "JRC2018Unisex"
},
"image_folder": "http://www.virtualflybrain.org/data/VFB/i/jrch/k0e2/VFB_00101567/"
},
"channel": {
"symbol": "",
"iri": "http://virtualflybrain.org/reports/VFBc_jrchk0e2",
"types": [
"Entity",
"Individual"
],
"short_form": "VFBc_jrchk0e2",
"label": "MBON01(y5B\\'2a)_R - 612371421_c"
},
"imaging_technique": {
"symbol": "FIB-SEM",
"iri": "http://purl.obolibrary.org/obo/FBbi_00050000",
"types": [
"Entity",
"Class"
],
"short_form": "FBbi_00050000",
"label": "focussed ion beam scanning electron microscopy (FIB-SEM)"
}
}
},
{
"anatomy": {
"symbol": "",
"iri": "http://virtualflybrain.org/reports/VFB_jrchk0e3",
"types": [
"Entity",
"Adult",
"Anatomy",
"Cell",
"Glutamatergic",
"Individual",
"NBLAST",
"Nervous_system",
"Neuron",
"has_image",
"has_neuron_connectivity",
"has_region_connectivity"
],
"short_form": "VFB_jrchk0e3",
"label": "MBON01(y5B\\'2a)_L (FlyEM-HB:673509195)"
},
"channel_image": {
"image": {
"template_channel": {
"symbol": "",
"iri": "http://virtualflybrain.org/reports/VFBc_00101384",
"types": [
"Entity",
"Individual",
"Template"
],
"short_form": "VFBc_00101384",
"label": "JRC_FlyEM_Hemibrain_c"
},
"index": [],
"template_anatomy": {
"symbol": "",
"iri": "http://virtualflybrain.org/reports/VFB_00101384",
"types": [
"Entity",
"Adult",
"Anatomy",
"Individual",
"Nervous_system",
"Template",
"has_image"
],
"short_form": "VFB_00101384",
"label": "JRC_FlyEM_Hemibrain"
},
"image_folder": "http://www.virtualflybrain.org/data/VFB/i/jrch/k0e3/VFB_00101384/"
},
"channel": {
"symbol": "",
"iri": "http://virtualflybrain.org/reports/VFBc_jrchk0e3",
"types": [
"Entity",
"Individual"
],
"short_form": "VFBc_jrchk0e3",
"label": "MBON01(y5B\\'2a)_L - 673509195_c"
},
"imaging_technique": {
"symbol": "FIB-SEM",
"iri": "http://purl.obolibrary.org/obo/FBbi_00050000",
"types": [
"Entity",
"Class"
],
"short_form": "FBbi_00050000",
"label": "focussed ion beam scanning electron microscopy (FIB-SEM)"
}
}
},
{
"anatomy": {
"symbol": "",
"iri": "http://virtualflybrain.org/reports/VFB_jrchk0e3",
"types": [
"Entity",
"Adult",
"Anatomy",
"Cell",
"Glutamatergic",
"Individual",
"NBLAST",
"Nervous_system",
"Neuron",
"has_image",
"has_neuron_connectivity",
"has_region_connectivity"
],
"short_form": "VFB_jrchk0e3",
"label": "MBON01(y5B\\'2a)_L (FlyEM-HB:673509195)"
},
"channel_image": {
"image": {
"template_channel": {
"symbol": "",
"iri": "http://virtualflybrain.org/reports/VFBc_00101567",
"types": [
"Entity",
"Individual",
"Template"
],
"short_form": "VFBc_00101567",
"label": "JRC2018Unisex_c"
},
"index": [],
"template_anatomy": {
"symbol": "",
"iri": "http://virtualflybrain.org/reports/VFB_00101567",
"types": [
"Entity",
"Adult",
"Anatomy",
"Individual",
"Nervous_system",
"Template",
"has_image"
],
"short_form": "VFB_00101567",
"label": "JRC2018Unisex"
},
"image_folder": "http://www.virtualflybrain.org/data/VFB/i/jrch/k0e3/VFB_00101567/"
},
"channel": {
"symbol": "",
"iri": "http://virtualflybrain.org/reports/VFBc_jrchk0e3",
"types": [
"Entity",
"Individual"
],
"short_form": "VFBc_jrchk0e3",
"label": "MBON01(y5B\\'2a)_L - 673509195_c"
},
"imaging_technique": {
"symbol": "FIB-SEM",
"iri": "http://purl.obolibrary.org/obo/FBbi_00050000",
"types": [
"Entity",
"Class"
],
"short_form": "FBbi_00050000",
"label": "focussed ion beam scanning electron microscopy (FIB-SEM)"
}
}
}
],
"pub_syn": [
{
"synonym": {
"scope": "has_exact_synonym",
"label": "MBON-01",
"type": ""
},
"pub": {
"core": {
"symbol": "",
"iri": "http://flybase.org/reports/FBrf0227179",
"types": [
"Entity",
"Individual",
"pub"
],
"short_form": "FBrf0227179",
"label": "Aso et al., 2014, eLife 3: e04577"
},
"FlyBase": "FBrf0227179",
"PubMed": "25535793",
"DOI": "10.7554/eLife.04577"
}
},
{
"synonym": {
"scope": "has_exact_synonym",
"label": "MBON01",
"type": ""
},
"pub": {
"core": {
"symbol": "",
"iri": "http://flybase.org/reports/FBrf0248215",
"types": [
"Entity",
"Individual",
"pub"
],
"short_form": "FBrf0248215",
"label": "Li et al., 2020, eLife 9: e62576"
},
"FlyBase": "",
"PubMed": "33315010",
"DOI": "10.7554/eLife.62576"
}
},
{
"synonym": {
"scope": "has_exact_synonym",
"label": "MBON-gamma5beta'2a",
"type": ""
},
"pub": {
"core": {
"symbol": "",
"iri": "http://flybase.org/reports/FBrf0227179",
"types": [
"Entity",
"Individual",
"pub"
],
"short_form": "FBrf0227179",
"label": "Aso et al., 2014, eLife 3: e04577"
},
"FlyBase": "FBrf0227179",
"PubMed": "25535793",
"DOI": "10.7554/eLife.04577"
}
},
{
"synonym": {
"scope": "has_exact_synonym",
"label": "MB-M6",
"type": ""
},
"pub": {
"core": {
"symbol": "",
"iri": "http://flybase.org/reports/FBrf0205263",
"types": [
"Entity",
"Individual",
"pub"
],
"short_form": "FBrf0205263",
"label": "Tanaka et al., 2008, J. Comp. Neurol. 508(5): 711--755"
},
"FlyBase": "",
"PubMed": "18395827",
"DOI": "10.1002/cne.21692"
}
},
{
"synonym": {
"scope": "has_exact_synonym",
"label": "M6",
"type": ""
},
"pub": {
"core": {
"symbol": "",
"iri": "http://flybase.org/reports/FBrf0228212",
"types": [
"Entity",
"Individual",
"pub"
],
"short_form": "FBrf0228212",
"label": "Owald et al., 2015, Neuron 86(2): 417--427"
},
"FlyBase": "",
"PubMed": "25864636",
"DOI": "10.1016/j.neuron.2015.03.025"
}
},
{
"synonym": {
"scope": "has_exact_synonym",
"label": "mushroom body medial lobe arborizing neuron 6",
"type": ""
},
"pub": {
"core": {
"symbol": "",
"iri": "http://flybase.org/reports/Unattributed",
"types": [
"Entity",
"Individual",
"pub"
],
"short_form": "Unattributed",
"label": ""
},
"FlyBase": "",
"PubMed": "",
"DOI": ""
}
}
],
"def_pubs": [
{
"core": {
"symbol": "",
"iri": "http://flybase.org/reports/FBrf0228475",
"types": [
"Entity",
"Individual",
"pub"
],
"short_form": "FBrf0228475",
"label": "Bouzaiane et al., 2015, Cell Rep. 11(8): 1280--1292"
},
"FlyBase": "",
"PubMed": "25981036",
"DOI": "10.1016/j.celrep.2015.04.044"
},
{
"core": {
"symbol": "",
"iri": "http://flybase.org/reports/FBrf0248215",
"types": [
"Entity",
"Individual",
"pub"
],
"short_form": "FBrf0248215",
"label": "Li et al., 2020, eLife 9: e62576"
},
"FlyBase": "",
"PubMed": "33315010",
"DOI": "10.7554/eLife.62576"
},
{
"core": {
"symbol": "",
"iri": "http://flybase.org/reports/FBrf0227179",
"types": [
"Entity",
"Individual",
"pub"
],
"short_form": "FBrf0227179",
"label": "Aso et al., 2014, eLife 3: e04577"
},
"FlyBase": "FBrf0227179",
"PubMed": "25535793",
"DOI": "10.7554/eLife.04577"
},
{
"core": {
"symbol": "",
"iri": "http://flybase.org/reports/FBrf0205263",
"types": [
"Entity",
"Individual",
"pub"
],
"short_form": "FBrf0205263",
"label": "Tanaka et al., 2008, J. Comp. Neurol. 508(5): 711--755"
},
"FlyBase": "",
"PubMed": "18395827",
"DOI": "10.1002/cne.21692"
},
{
"core": {
"symbol": "",
"iri": "http://flybase.org/reports/FBrf0235522",
"types": [
"Entity",
"Individual",
"pub"
],
"short_form": "FBrf0235522",
"label": "Shyu et al., 2017, Nat. Commun. 8: 15230"
},
"FlyBase": "",
"PubMed": "28504254",
"DOI": "10.1038/ncomms15230"
},
{
"core": {
"symbol": "",
"iri": "http://flybase.org/reports/FBrf0228212",
"types": [
"Entity",
"Individual",
"pub"
],
"short_form": "FBrf0228212",
"label": "Owald et al., 2015, Neuron 86(2): 417--427"
},
"FlyBase": "",
"PubMed": "25864636",
"DOI": "10.1016/j.neuron.2015.03.025"
}
]
}
Feedback
Was this page helpful?
Glad to hear it! Please tell us how we can improve.
Sorry to hear that. Please tell us how we can improve.