mushroom body output neuron 3 [FBbt_00100232]
Glutamatergic neuron whose cell body is located on the superior neuropils of each hemisphere, anterior to the pars intercerebralis of the adult brain (Tanaka et al., 2008; Aso et al., 2014). The cell body fiber crosses the midline, and is sent ventrally towards the contralateral medial lobe, before making dendritic arborizations in the anterior and posterior layers of beta’ lobe slice 2 (Aso et al., 2014). The main axon projects to the crepine and superior medial protocerebrum (SMP) on the same side, with a minor axon extending to the ipsilateral side (Aso et al., 2014). These neurons have synaptic connections with protocerebral anterior medial (PAM) cluster neurons in the SMP and in the tip of the mushroom body horizontal lobe (Owald et al., 2015). They are also involved in long-term memory formation and synapse onto the dorsal anterior lateral neurons of the protocerebrum (Wu et al., 2017). They are electrically synapsed by Kenyon cells via gap junctions (Liu et al., 2016). There is one of these cells per hemisphere (Aso et al., 2014; Li et al., 2020). Synapsing with PAM neurons determined by GRASP (Owald et al., 2015). Blocking protein synthesis in this neuron impairs normal long-term memory formation in response to negative odor-associated learning (Wu et al., 2017). GRASP was also used to show connectivity with the DAL neurons (Wu et al., 2017).
Note
This page displays the raw VFB json record for this term. Please use the link below to open the term inside the Virtual Fly Brain viewerOpen mushroom body output neuron 3 in VFB
Example Images
VFB Term Json
{
"term": {
"core": {
"iri": "http://purl.obolibrary.org/obo/FBbt_00100232",
"symbol": "MBON03",
"types": [
"Entity",
"Adult",
"Anatomy",
"Cell",
"Class",
"Glutamatergic",
"Nervous_system",
"Neuron"
],
"short_form": "FBbt_00100232",
"label": "mushroom body output neuron 3"
},
"description": [
"Glutamatergic neuron whose cell body is located on the superior neuropils of each hemisphere, anterior to the pars intercerebralis of the adult brain (Tanaka et al., 2008; Aso et al., 2014). The cell body fiber crosses the midline, and is sent ventrally towards the contralateral medial lobe, before making dendritic arborizations in the anterior and posterior layers of beta' lobe slice 2 (Aso et al., 2014). The main axon projects to the crepine and superior medial protocerebrum (SMP) on the same side, with a minor axon extending to the ipsilateral side (Aso et al., 2014). These neurons have synaptic connections with protocerebral anterior medial (PAM) cluster neurons in the SMP and in the tip of the mushroom body horizontal lobe (Owald et al., 2015). They are also involved in long-term memory formation and synapse onto the dorsal anterior lateral neurons of the protocerebrum (Wu et al., 2017). They are electrically synapsed by Kenyon cells via gap junctions (Liu et al., 2016). There is one of these cells per hemisphere (Aso et al., 2014; Li et al., 2020)."
],
"comment": [
"Synapsing with PAM neurons determined by GRASP (Owald et al., 2015). Blocking protein synthesis in this neuron impairs normal long-term memory formation in response to negative odor-associated learning (Wu et al., 2017). GRASP was also used to show connectivity with the DAL neurons (Wu et al., 2017)."
]
},
"query": "Get JSON for Class",
"version": "44725ae",
"parents": [
{
"symbol": "",
"iri": "http://purl.obolibrary.org/obo/FBbt_00058208",
"types": [
"Entity",
"Adult",
"Anatomy",
"Cell",
"Class",
"Glutamatergic",
"Nervous_system",
"Neuron"
],
"short_form": "FBbt_00058208",
"label": "adult glutamatergic neuron"
},
{
"symbol": "",
"iri": "http://purl.obolibrary.org/obo/FBbt_00049843",
"types": [
"Entity",
"Adult",
"Anatomy",
"Cell",
"Class",
"Nervous_system",
"Neuron"
],
"short_form": "FBbt_00049843",
"label": "adult typical mushroom body output neuron"
}
],
"relationships": [
{
"relation": {
"iri": "http://purl.obolibrary.org/obo/RO_0000053",
"label": "bearer of",
"type": "bearer_of"
},
"object": {
"symbol": "",
"iri": "http://purl.obolibrary.org/obo/PATO_0000618",
"types": [
"Entity",
"Class"
],
"short_form": "PATO_0000618",
"label": "bilateral"
}
},
{
"relation": {
"iri": "http://purl.obolibrary.org/obo/RO_0002216",
"label": "capable_of_part_of",
"type": "capable_of_part_of"
},
"object": {
"symbol": "",
"iri": "http://purl.obolibrary.org/obo/GO_0007616",
"types": [
"Entity",
"Class"
],
"short_form": "GO_0007616",
"label": "long-term memory"
}
},
{
"relation": {
"iri": "http://purl.obolibrary.org/obo/RO_0002100",
"label": "has soma location",
"type": "has_soma_location"
},
"object": {
"symbol": "",
"iri": "http://purl.obolibrary.org/obo/FBbt_00100308",
"types": [
"Entity",
"Adult",
"Anatomy",
"Class",
"Nervous_system"
],
"short_form": "FBbt_00100308",
"label": "adult superior brain cell body rind"
}
},
{
"relation": {
"iri": "http://purl.obolibrary.org/obo/BFO_0000050",
"label": "is part of",
"type": "part_of"
},
"object": {
"symbol": "",
"iri": "http://purl.obolibrary.org/obo/FBbt_00003624",
"types": [
"Entity",
"Adult",
"Anatomy",
"Class",
"Nervous_system"
],
"short_form": "FBbt_00003624",
"label": "adult brain"
}
},
{
"relation": {
"iri": "http://purl.obolibrary.org/obo/RO_0013008",
"label": "receives synaptic input from neuron",
"type": "receives_synaptic_input_from_neuron"
},
"object": {
"symbol": "PAM",
"iri": "http://purl.obolibrary.org/obo/FBbt_00100214",
"types": [
"Entity",
"Adult",
"Anatomy",
"Cell",
"Class",
"Dopaminergic",
"Nervous_system",
"Neuron"
],
"short_form": "FBbt_00100214",
"label": "dopaminergic PAM neuron"
}
},
{
"relation": {
"iri": "http://purl.obolibrary.org/obo/RO_0013002",
"label": "receives synaptic input in region",
"type": "receives_synaptic_input_in_region"
},
"object": {
"symbol": "",
"iri": "http://purl.obolibrary.org/obo/FBbt_00047093",
"types": [
"Entity",
"Adult",
"Anatomy",
"Class",
"Nervous_system",
"Synaptic_neuropil",
"Synaptic_neuropil_subdomain"
],
"short_form": "FBbt_00047093",
"label": "mushroom body anterior layer of beta\\' lobe slice 2"
}
},
{
"relation": {
"iri": "http://purl.obolibrary.org/obo/RO_0013002",
"label": "receives synaptic input in region",
"type": "receives_synaptic_input_in_region"
},
"object": {
"symbol": "",
"iri": "http://purl.obolibrary.org/obo/FBbt_00047094",
"types": [
"Entity",
"Adult",
"Anatomy",
"Class",
"Nervous_system",
"Synaptic_neuropil",
"Synaptic_neuropil_subdomain"
],
"short_form": "FBbt_00047094",
"label": "mushroom body posterior layer of beta' lobe slice 2"
}
},
{
"relation": {
"iri": "http://purl.obolibrary.org/obo/RO_0013009",
"label": "sends_synaptic_output_to_cell",
"type": "sends_synaptic_output_to_cell"
},
"object": {
"symbol": "",
"iri": "http://purl.obolibrary.org/obo/FBbt_00110034",
"types": [
"Entity",
"Adult",
"Anatomy",
"Cell",
"Class",
"Nervous_system",
"Neuron"
],
"short_form": "FBbt_00110034",
"label": "dorsal anterior lateral neuron of the protocerebrum"
}
},
{
"relation": {
"iri": "http://purl.obolibrary.org/obo/RO_0013009",
"label": "sends_synaptic_output_to_cell",
"type": "sends_synaptic_output_to_cell"
},
"object": {
"symbol": "PAM",
"iri": "http://purl.obolibrary.org/obo/FBbt_00100214",
"types": [
"Entity",
"Adult",
"Anatomy",
"Cell",
"Class",
"Dopaminergic",
"Nervous_system",
"Neuron"
],
"short_form": "FBbt_00100214",
"label": "dopaminergic PAM neuron"
}
},
{
"relation": {
"iri": "http://purl.obolibrary.org/obo/RO_0013003",
"label": "sends_synaptic_output_to_region",
"type": "sends_synaptic_output_to_region"
},
"object": {
"symbol": "",
"iri": "http://purl.obolibrary.org/obo/FBbt_00045037",
"types": [
"Entity",
"Adult",
"Anatomy",
"Class",
"Nervous_system",
"Synaptic_neuropil",
"Synaptic_neuropil_domain"
],
"short_form": "FBbt_00045037",
"label": "adult crepine"
}
},
{
"relation": {
"iri": "http://purl.obolibrary.org/obo/RO_0013003",
"label": "sends_synaptic_output_to_region",
"type": "sends_synaptic_output_to_region"
},
"object": {
"symbol": "",
"iri": "http://purl.obolibrary.org/obo/FBbt_00007055",
"types": [
"Entity",
"Adult",
"Anatomy",
"Class",
"Nervous_system",
"Synaptic_neuropil",
"Synaptic_neuropil_domain"
],
"short_form": "FBbt_00007055",
"label": "superior medial protocerebrum"
}
}
],
"xrefs": [
{
"link_base": "https://flybrain-ndb.virtualflybrain.org/neuronrec-",
"site": {
"symbol": "",
"iri": "http://virtualflybrain.org/reports/FlyBrain_NDB",
"types": [
"Entity",
"Individual",
"Site"
],
"short_form": "FlyBrain_NDB",
"label": "FlyBrain NeuronDB"
},
"is_data_source": false,
"link_postfix": [
".html"
],
"icon": "http://flybrain-ndb.virtualflybrain.org/NDB_title260.gif",
"accession": "10457",
"link_text": "mushroom body output neuron 3 on FlyBrain NeuronDB",
"homepage": "https://flybrain-ndb.virtualflybrain.org"
}
],
"anatomy_channel_image": [
{
"anatomy": {
"symbol": "",
"iri": "http://virtualflybrain.org/reports/VFB_jrchk0e7",
"types": [
"Entity",
"Adult",
"Anatomy",
"Cell",
"Glutamatergic",
"Individual",
"NBLAST",
"Nervous_system",
"Neuron",
"has_image",
"has_neuron_connectivity",
"has_region_connectivity"
],
"short_form": "VFB_jrchk0e7",
"label": "MBON03(B\\'2mp)_R (FlyEM-HB:487925037)"
},
"channel_image": {
"image": {
"template_channel": {
"symbol": "",
"iri": "http://virtualflybrain.org/reports/VFBc_00101384",
"types": [
"Entity",
"Individual",
"Template"
],
"short_form": "VFBc_00101384",
"label": "JRC_FlyEM_Hemibrain_c"
},
"index": [],
"template_anatomy": {
"symbol": "",
"iri": "http://virtualflybrain.org/reports/VFB_00101384",
"types": [
"Entity",
"Adult",
"Anatomy",
"Individual",
"Nervous_system",
"Template",
"has_image"
],
"short_form": "VFB_00101384",
"label": "JRC_FlyEM_Hemibrain"
},
"image_folder": "http://www.virtualflybrain.org/data/VFB/i/jrch/k0e7/VFB_00101384/"
},
"channel": {
"symbol": "",
"iri": "http://virtualflybrain.org/reports/VFBc_jrchk0e7",
"types": [
"Entity",
"Individual"
],
"short_form": "VFBc_jrchk0e7",
"label": "MBON03(B\\'2mp)_R - 487925037_c"
},
"imaging_technique": {
"symbol": "FIB-SEM",
"iri": "http://purl.obolibrary.org/obo/FBbi_00050000",
"types": [
"Entity",
"Class"
],
"short_form": "FBbi_00050000",
"label": "focussed ion beam scanning electron microscopy (FIB-SEM)"
}
}
},
{
"anatomy": {
"symbol": "",
"iri": "http://virtualflybrain.org/reports/VFB_jrchk0e7",
"types": [
"Entity",
"Adult",
"Anatomy",
"Cell",
"Glutamatergic",
"Individual",
"NBLAST",
"Nervous_system",
"Neuron",
"has_image",
"has_neuron_connectivity",
"has_region_connectivity"
],
"short_form": "VFB_jrchk0e7",
"label": "MBON03(B\\'2mp)_R (FlyEM-HB:487925037)"
},
"channel_image": {
"image": {
"template_channel": {
"symbol": "",
"iri": "http://virtualflybrain.org/reports/VFBc_00101567",
"types": [
"Entity",
"Individual",
"Template"
],
"short_form": "VFBc_00101567",
"label": "JRC2018Unisex_c"
},
"index": [],
"template_anatomy": {
"symbol": "",
"iri": "http://virtualflybrain.org/reports/VFB_00101567",
"types": [
"Entity",
"Adult",
"Anatomy",
"Individual",
"Nervous_system",
"Template",
"has_image"
],
"short_form": "VFB_00101567",
"label": "JRC2018Unisex"
},
"image_folder": "http://www.virtualflybrain.org/data/VFB/i/jrch/k0e7/VFB_00101567/"
},
"channel": {
"symbol": "",
"iri": "http://virtualflybrain.org/reports/VFBc_jrchk0e7",
"types": [
"Entity",
"Individual"
],
"short_form": "VFBc_jrchk0e7",
"label": "MBON03(B\\'2mp)_R - 487925037_c"
},
"imaging_technique": {
"symbol": "FIB-SEM",
"iri": "http://purl.obolibrary.org/obo/FBbi_00050000",
"types": [
"Entity",
"Class"
],
"short_form": "FBbi_00050000",
"label": "focussed ion beam scanning electron microscopy (FIB-SEM)"
}
}
},
{
"anatomy": {
"symbol": "",
"iri": "http://virtualflybrain.org/reports/VFB_00101381",
"types": [
"Entity",
"Adult",
"Anatomy",
"Cell",
"Glutamatergic",
"Individual",
"NBLAST",
"Nervous_system",
"Neuron",
"has_image",
"has_neuron_connectivity"
],
"short_form": "VFB_00101381",
"label": "MBON-B'2mp_R (FAFB:4291899)"
},
"channel_image": {
"image": {
"template_channel": {
"symbol": "",
"iri": "http://virtualflybrain.org/reports/VFBc_00017894",
"types": [
"Entity",
"Individual",
"Template",
"VFB"
],
"short_form": "VFBc_00017894",
"label": "JFRC2_template_c"
},
"index": [],
"template_anatomy": {
"symbol": "",
"iri": "http://virtualflybrain.org/reports/VFB_00017894",
"types": [
"Entity",
"Adult",
"Anatomy",
"Individual",
"Nervous_system",
"Template",
"VFB",
"has_image"
],
"short_form": "VFB_00017894",
"label": "adult brain template JFRC2"
},
"image_folder": "http://www.virtualflybrain.org/data/VFB/i/0010/1381/"
},
"channel": {
"symbol": "",
"iri": "http://virtualflybrain.org/reports/VFBc_00101381",
"types": [
"Entity",
"Individual"
],
"short_form": "VFBc_00101381",
"label": "Neuron 4291900 Putative MBON-B\\'2mp_c"
},
"imaging_technique": {
"symbol": "TEM",
"iri": "http://purl.obolibrary.org/obo/FBbi_00000258",
"types": [
"Entity",
"Class"
],
"short_form": "FBbi_00000258",
"label": "transmission electron microscopy (TEM)"
}
}
},
{
"anatomy": {
"symbol": "",
"iri": "http://virtualflybrain.org/reports/VFB_00101381",
"types": [
"Entity",
"Adult",
"Anatomy",
"Cell",
"Glutamatergic",
"Individual",
"NBLAST",
"Nervous_system",
"Neuron",
"has_image",
"has_neuron_connectivity"
],
"short_form": "VFB_00101381",
"label": "MBON-B'2mp_R (FAFB:4291899)"
},
"channel_image": {
"image": {
"template_channel": {
"symbol": "",
"iri": "http://virtualflybrain.org/reports/VFBc_00101567",
"types": [
"Entity",
"Individual",
"Template"
],
"short_form": "VFBc_00101567",
"label": "JRC2018Unisex_c"
},
"index": [],
"template_anatomy": {
"symbol": "",
"iri": "http://virtualflybrain.org/reports/VFB_00101567",
"types": [
"Entity",
"Adult",
"Anatomy",
"Individual",
"Nervous_system",
"Template",
"has_image"
],
"short_form": "VFB_00101567",
"label": "JRC2018Unisex"
},
"image_folder": "http://www.virtualflybrain.org/data/VFB/i/0010/1381/VFB_00101567/"
},
"channel": {
"symbol": "",
"iri": "http://virtualflybrain.org/reports/VFBc_00101381",
"types": [
"Entity",
"Individual"
],
"short_form": "VFBc_00101381",
"label": "Neuron 4291900 Putative MBON-B\\'2mp_c"
},
"imaging_technique": {
"symbol": "TEM",
"iri": "http://purl.obolibrary.org/obo/FBbi_00000258",
"types": [
"Entity",
"Class"
],
"short_form": "FBbi_00000258",
"label": "transmission electron microscopy (TEM)"
}
}
},
{
"anatomy": {
"symbol": "",
"iri": "http://virtualflybrain.org/reports/VFB_jrchk0e6",
"types": [
"Entity",
"Adult",
"Anatomy",
"Cell",
"Glutamatergic",
"Individual",
"NBLAST",
"Nervous_system",
"Neuron",
"has_image",
"has_neuron_connectivity",
"has_region_connectivity"
],
"short_form": "VFB_jrchk0e6",
"label": "MBON03(B\\'2mp)_L (FlyEM-HB:612738462)"
},
"channel_image": {
"image": {
"template_channel": {
"symbol": "",
"iri": "http://virtualflybrain.org/reports/VFBc_00101567",
"types": [
"Entity",
"Individual",
"Template"
],
"short_form": "VFBc_00101567",
"label": "JRC2018Unisex_c"
},
"index": [],
"template_anatomy": {
"symbol": "",
"iri": "http://virtualflybrain.org/reports/VFB_00101567",
"types": [
"Entity",
"Adult",
"Anatomy",
"Individual",
"Nervous_system",
"Template",
"has_image"
],
"short_form": "VFB_00101567",
"label": "JRC2018Unisex"
},
"image_folder": "http://www.virtualflybrain.org/data/VFB/i/jrch/k0e6/VFB_00101567/"
},
"channel": {
"symbol": "",
"iri": "http://virtualflybrain.org/reports/VFBc_jrchk0e6",
"types": [
"Entity",
"Individual"
],
"short_form": "VFBc_jrchk0e6",
"label": "MBON03(B\\'2mp)_L - 612738462_c"
},
"imaging_technique": {
"symbol": "FIB-SEM",
"iri": "http://purl.obolibrary.org/obo/FBbi_00050000",
"types": [
"Entity",
"Class"
],
"short_form": "FBbi_00050000",
"label": "focussed ion beam scanning electron microscopy (FIB-SEM)"
}
}
}
],
"pub_syn": [
{
"synonym": {
"scope": "has_exact_synonym",
"label": "M4beta'",
"type": ""
},
"pub": {
"core": {
"symbol": "",
"iri": "http://flybase.org/reports/FBrf0228212",
"types": [
"Entity",
"Individual",
"pub"
],
"short_form": "FBrf0228212",
"label": "Owald et al., 2015, Neuron 86(2): 417--427"
},
"FlyBase": "",
"PubMed": "25864636",
"DOI": "10.1016/j.neuron.2015.03.025"
}
},
{
"synonym": {
"scope": "has_exact_synonym",
"label": "MBON-beta'2mp",
"type": ""
},
"pub": {
"core": {
"symbol": "",
"iri": "http://flybase.org/reports/FBrf0227179",
"types": [
"Entity",
"Individual",
"pub"
],
"short_form": "FBrf0227179",
"label": "Aso et al., 2014, eLife 3: e04577"
},
"FlyBase": "FBrf0227179",
"PubMed": "25535793",
"DOI": "10.7554/eLife.04577"
}
},
{
"synonym": {
"scope": "has_exact_synonym",
"label": "MBON-03",
"type": ""
},
"pub": {
"core": {
"symbol": "",
"iri": "http://flybase.org/reports/FBrf0227179",
"types": [
"Entity",
"Individual",
"pub"
],
"short_form": "FBrf0227179",
"label": "Aso et al., 2014, eLife 3: e04577"
},
"FlyBase": "FBrf0227179",
"PubMed": "25535793",
"DOI": "10.7554/eLife.04577"
}
},
{
"synonym": {
"scope": "has_exact_synonym",
"label": "MB-M4",
"type": ""
},
"pub": {
"core": {
"symbol": "",
"iri": "http://flybase.org/reports/FBrf0205263",
"types": [
"Entity",
"Individual",
"pub"
],
"short_form": "FBrf0205263",
"label": "Tanaka et al., 2008, J. Comp. Neurol. 508(5): 711--755"
},
"FlyBase": "",
"PubMed": "18395827",
"DOI": "10.1002/cne.21692"
}
},
{
"synonym": {
"scope": "has_exact_synonym",
"label": "MBON03",
"type": ""
},
"pub": {
"core": {
"symbol": "",
"iri": "http://flybase.org/reports/FBrf0248215",
"types": [
"Entity",
"Individual",
"pub"
],
"short_form": "FBrf0248215",
"label": "Li et al., 2020, eLife 9: e62576"
},
"FlyBase": "",
"PubMed": "33315010",
"DOI": "10.7554/eLife.62576"
}
},
{
"synonym": {
"scope": "has_exact_synonym",
"label": "mushroom body medial lobe arborizing neuron 4",
"type": ""
},
"pub": {
"core": {
"symbol": "",
"iri": "http://flybase.org/reports/Unattributed",
"types": [
"Entity",
"Individual",
"pub"
],
"short_form": "Unattributed",
"label": ""
},
"FlyBase": "",
"PubMed": "",
"DOI": ""
}
}
],
"def_pubs": [
{
"core": {
"symbol": "",
"iri": "http://flybase.org/reports/FBrf0232676",
"types": [
"Entity",
"Individual",
"pub"
],
"short_form": "FBrf0232676",
"label": "Liu et al., 2016, eLife 5: e13238"
},
"FlyBase": "",
"PubMed": "27218450",
"DOI": "10.7554/eLife.13238"
},
{
"core": {
"symbol": "",
"iri": "http://flybase.org/reports/FBrf0236302",
"types": [
"Entity",
"Individual",
"pub"
],
"short_form": "FBrf0236302",
"label": "Wu et al., 2017, Sci. Rep. 7(1): 7112"
},
"FlyBase": "",
"PubMed": "28769066",
"DOI": "10.1038/s41598-017-07600-2"
},
{
"core": {
"symbol": "",
"iri": "http://flybase.org/reports/FBrf0228212",
"types": [
"Entity",
"Individual",
"pub"
],
"short_form": "FBrf0228212",
"label": "Owald et al., 2015, Neuron 86(2): 417--427"
},
"FlyBase": "",
"PubMed": "25864636",
"DOI": "10.1016/j.neuron.2015.03.025"
},
{
"core": {
"symbol": "",
"iri": "http://flybase.org/reports/FBrf0227179",
"types": [
"Entity",
"Individual",
"pub"
],
"short_form": "FBrf0227179",
"label": "Aso et al., 2014, eLife 3: e04577"
},
"FlyBase": "FBrf0227179",
"PubMed": "25535793",
"DOI": "10.7554/eLife.04577"
},
{
"core": {
"symbol": "",
"iri": "http://flybase.org/reports/FBrf0205263",
"types": [
"Entity",
"Individual",
"pub"
],
"short_form": "FBrf0205263",
"label": "Tanaka et al., 2008, J. Comp. Neurol. 508(5): 711--755"
},
"FlyBase": "",
"PubMed": "18395827",
"DOI": "10.1002/cne.21692"
},
{
"core": {
"symbol": "",
"iri": "http://flybase.org/reports/FBrf0248215",
"types": [
"Entity",
"Individual",
"pub"
],
"short_form": "FBrf0248215",
"label": "Li et al., 2020, eLife 9: e62576"
},
"FlyBase": "",
"PubMed": "33315010",
"DOI": "10.7554/eLife.62576"
}
]
}
Feedback
Was this page helpful?
Glad to hear it! Please tell us how we can improve.
Sorry to hear that. Please tell us how we can improve.