T neuron T5 [FBbt_00003736]
T neuron whose cell body fiber projects through the lobula plate with little or no arborization before bifurcating in the second optic chiasm with one branch forming a fine terminal arborization in lobula layer 1 and the other doubling back to form bleb-type arborizations in the lobula plate. In lobula layer 1, it receives most of its input from the transmedullary neurons Tm1, Tm2 and Tm9 (Shinomiya et al., 2014). It is a cholinergic neuron (Mauss et al., 2014; Shinomiya et al., 2014). There are a large number of these cells, which are generated from neuroblasts that amplify by symmetric division (type III) before generating the T5 (and T4) neurons (Mora et al., 2018). Pre- versus postsynaptic innervation judged by scoring of terminal morphology from figures in Fischbach and Dittrich (1989) as assessed by FlyBrain Neuron DB. The neurotransmitter was assessed with a split-GAL4 strategy using a Chat-DBD allele (FBal0198074) (Mauss et al., 2014) and single-cell transcript profiling (Shinomiya et al., 2014). Connectivity in the lobula was assessed by serial section electron microscopy of a single column (Shinomiya et al., 2014).
Note
This page displays the raw VFB json record for this term. Please use the link below to open the term inside the Virtual Fly Brain viewerVFB Term Json
{
"term": {
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"iri": "http://purl.obolibrary.org/obo/FBbt_00003736",
"symbol": "T5",
"types": [
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],
"short_form": "FBbt_00003736",
"label": "T neuron T5"
},
"description": [
"T neuron whose cell body fiber projects through the lobula plate with little or no arborization before bifurcating in the second optic chiasm with one branch forming a fine terminal arborization in lobula layer 1 and the other doubling back to form bleb-type arborizations in the lobula plate. In lobula layer 1, it receives most of its input from the transmedullary neurons Tm1, Tm2 and Tm9 (Shinomiya et al., 2014). It is a cholinergic neuron (Mauss et al., 2014; Shinomiya et al., 2014). There are a large number of these cells, which are generated from neuroblasts that amplify by symmetric division (type III) before generating the T5 (and T4) neurons (Mora et al., 2018)."
],
"comment": [
"Pre- versus postsynaptic innervation judged by scoring of terminal morphology from figures in Fischbach and Dittrich (1989) as assessed by FlyBrain Neuron DB. The neurotransmitter was assessed with a split-GAL4 strategy using a Chat-DBD allele (FBal0198074) (Mauss et al., 2014) and single-cell transcript profiling (Shinomiya et al., 2014). Connectivity in the lobula was assessed by serial section electron microscopy of a single column (Shinomiya et al., 2014)."
]
},
"query": "Get JSON for Class",
"version": "44725ae",
"parents": [
{
"symbol": "",
"iri": "http://purl.obolibrary.org/obo/FBbt_00058205",
"types": [
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"short_form": "FBbt_00058205",
"label": "adult cholinergic neuron"
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"iri": "http://purl.obolibrary.org/obo/FBbt_00003726",
"types": [
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"short_form": "FBbt_00003726",
"label": "T neuron"
}
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"label": "sends_synaptic_output_to_region",
"type": "sends_synaptic_output_to_region"
},
"object": {
"symbol": "",
"iri": "http://purl.obolibrary.org/obo/FBbt_00003885",
"types": [
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"short_form": "FBbt_00003885",
"label": "lobula plate"
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{
"relation": {
"iri": "http://purl.obolibrary.org/obo/RO_0013002",
"label": "receives synaptic input in region",
"type": "receives_synaptic_input_in_region"
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"object": {
"symbol": "",
"iri": "http://purl.obolibrary.org/obo/FBbt_00003853",
"types": [
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"short_form": "FBbt_00003853",
"label": "lobula layer 1"
}
},
{
"relation": {
"iri": "http://purl.obolibrary.org/obo/RO_0013008",
"label": "receives synaptic input from neuron",
"type": "receives_synaptic_input_from_neuron"
},
"object": {
"symbol": "Tm2",
"iri": "http://purl.obolibrary.org/obo/FBbt_00003790",
"types": [
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],
"short_form": "FBbt_00003790",
"label": "transmedullary neuron Tm2"
}
},
{
"relation": {
"iri": "http://purl.obolibrary.org/obo/RO_0013008",
"label": "receives synaptic input from neuron",
"type": "receives_synaptic_input_from_neuron"
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"object": {
"symbol": "Tm1",
"iri": "http://purl.obolibrary.org/obo/FBbt_00003789",
"types": [
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"Adult",
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"Cell",
"Cholinergic",
"Class",
"Nervous_system",
"Neuron"
],
"short_form": "FBbt_00003789",
"label": "transmedullary neuron Tm1"
}
},
{
"relation": {
"iri": "http://purl.obolibrary.org/obo/RO_0013008",
"label": "receives synaptic input from neuron",
"type": "receives_synaptic_input_from_neuron"
},
"object": {
"symbol": "Tm9",
"iri": "http://purl.obolibrary.org/obo/FBbt_00003797",
"types": [
"Entity",
"Adult",
"Anatomy",
"Cell",
"Cholinergic",
"Class",
"Nervous_system",
"Neuron"
],
"short_form": "FBbt_00003797",
"label": "transmedullary neuron Tm9"
}
},
{
"relation": {
"iri": "http://purl.obolibrary.org/obo/RO_0002202",
"label": "develops from",
"type": "develops_from"
},
"object": {
"symbol": "",
"iri": "http://purl.obolibrary.org/obo/FBbt_00047992",
"types": [
"Entity",
"Anatomy",
"Cell",
"Class",
"Neuroblast"
],
"short_form": "FBbt_00047992",
"label": "type III neuroblast"
}
}
],
"xrefs": [],
"anatomy_channel_image": [],
"pub_syn": [
{
"synonym": {
"scope": "has_exact_synonym",
"label": "T5",
"type": ""
},
"pub": {
"core": {
"symbol": "",
"iri": "http://flybase.org/reports/FBrf0237184",
"types": [
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],
"short_form": "FBrf0237184",
"label": "Klapoetke et al., 2017, Nature 551(7679): 237--241"
},
"FlyBase": "FBrf0237184",
"PubMed": "29120418",
"DOI": "10.1038/nature24626"
}
}
],
"def_pubs": [
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"core": {
"symbol": "",
"iri": "http://flybase.org/reports/FBrf0238554",
"types": [
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],
"short_form": "FBrf0238554",
"label": "Mora et al., 2018, Dev. Cell 45(1): 53--66.e5"
},
"FlyBase": "",
"PubMed": "29576424",
"DOI": "10.1016/j.devcel.2018.02.023"
},
{
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"types": [
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],
"short_form": "FBrf0224060",
"label": "Mauss et al., 2014, J. Neurosci. 34(6): 2254--2263"
},
"FlyBase": "",
"PubMed": "24501364",
"DOI": "10.1523/JNEUROSCI.3938-13.2014"
},
{
"core": {
"symbol": "",
"iri": "http://flybase.org/reports/FBrf0225094",
"types": [
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],
"short_form": "FBrf0225094",
"label": "Shinomiya et al., 2014, Curr. Biol. 24(10): 1062--1070"
},
"FlyBase": "",
"PubMed": "24768048",
"DOI": "10.1016/j.cub.2014.03.051"
},
{
"core": {
"symbol": "",
"iri": "http://flybase.org/reports/FBrf0049410",
"types": [
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],
"short_form": "FBrf0049410",
"label": "Fischbach and Dittrich, 1989, Cell Tissue Res. 258(3): 441--475"
},
"FlyBase": "",
"PubMed": "",
"DOI": ""
}
]
}
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