VUM neuron of the dopaminergic GNG cluster [FBbt_00110128]

Unpaired dopaminergic neuron whose cell body is located ventromedially in the gnathal ganglion of the adult brain. It arborizes extensively in the ventroanterior area of the subesophageal zone with presynaptic terminals found throughout. It is involved in modulating the proboscis extension response (PER) with its activity being sufficient to trigger PER (Marella et al., 2012). The nature of the neurotransmitter was assessed by labelling cells with a tyrosine hydroxylase GAL4 driver (TH-GAL4) [FBtp0020119] and by using an antibody against tyrosine hydroxylase. Presynaptic terminals were labeled with synaptobrevin-GFP . Specific activation of the VUM neuron with UAS-TRPA1 [FBtp0040248] triggers proboscis extension. The tonic firing rate of the VUM neuron is low in conditions when the probability of proboscis extension is low (satiety) and increases in conditions when the probability of extension is high (hunger) (Marella et al., 2012).
Tags:

Open VUM neuron of the dopaminergic GNG cluster in VFB

VFB Term Json

{
    "term": {
        "core": {
            "iri": "http://purl.obolibrary.org/obo/FBbt_00110128",
            "symbol": "",
            "types": [
                "Entity",
                "Adult",
                "Anatomy",
                "Cell",
                "Class",
                "Dopaminergic",
                "Nervous_system",
                "Neuron"
            ],
            "short_form": "FBbt_00110128",
            "label": "VUM neuron of the dopaminergic GNG cluster"
        },
        "description": [
            "Unpaired dopaminergic neuron whose cell body is located ventromedially in the gnathal ganglion of the adult brain. It arborizes extensively in the ventroanterior area of the subesophageal zone with presynaptic terminals found throughout. It is involved in modulating the proboscis extension response (PER) with its activity being sufficient to trigger PER (Marella et al., 2012)."
        ],
        "comment": [
            "The nature of the neurotransmitter was assessed by labelling cells with a tyrosine hydroxylase GAL4 driver (TH-GAL4) [FBtp0020119] and by using an antibody against tyrosine hydroxylase. Presynaptic terminals were labeled with synaptobrevin-GFP . Specific activation of the VUM neuron with UAS-TRPA1 [FBtp0040248] triggers proboscis extension. The tonic firing rate of the VUM neuron is low in conditions when the probability of proboscis extension is low (satiety) and increases in conditions when the probability of extension is high (hunger) (Marella et al., 2012)."
        ]
    },
    "query": "Get JSON for Class",
    "version": "44725ae",
    "parents": [
        {
            "symbol": "",
            "iri": "http://purl.obolibrary.org/obo/FBbt_00048266",
            "types": [
                "Entity",
                "Adult",
                "Anatomy",
                "Cell",
                "Class",
                "Dopaminergic",
                "Nervous_system",
                "Neuron"
            ],
            "short_form": "FBbt_00048266",
            "label": "dopaminergic GNG neuron"
        }
    ],
    "relationships": [
        {
            "relation": {
                "iri": "http://purl.obolibrary.org/obo/BFO_0000050",
                "label": "is part of",
                "type": "part_of"
            },
            "object": {
                "symbol": "",
                "iri": "http://purl.obolibrary.org/obo/FBbt_00110639",
                "types": [
                    "Entity",
                    "Adult",
                    "Anatomy",
                    "Class",
                    "Nervous_system"
                ],
                "short_form": "FBbt_00110639",
                "label": "adult subesophageal zone"
            }
        },
        {
            "relation": {
                "iri": "http://purl.obolibrary.org/obo/RO_0013001",
                "label": "has_synaptic_IO_in",
                "type": "has_synaptic_IO_in"
            },
            "object": {
                "symbol": "",
                "iri": "http://purl.obolibrary.org/obo/FBbt_00110639",
                "types": [
                    "Entity",
                    "Adult",
                    "Anatomy",
                    "Class",
                    "Nervous_system"
                ],
                "short_form": "FBbt_00110639",
                "label": "adult subesophageal zone"
            }
        },
        {
            "relation": {
                "iri": "http://purl.obolibrary.org/obo/RO_0002216",
                "label": "capable_of_part_of",
                "type": "capable_of_part_of"
            },
            "object": {
                "symbol": "",
                "iri": "http://purl.obolibrary.org/obo/GO_0007637",
                "types": [
                    "Entity",
                    "Class"
                ],
                "short_form": "GO_0007637",
                "label": "proboscis extension reflex"
            }
        }
    ],
    "xrefs": [],
    "anatomy_channel_image": [],
    "pub_syn": [
        {
            "synonym": {
                "scope": "has_exact_synonym",
                "label": "TH-VUM",
                "type": ""
            },
            "pub": {
                "core": {
                    "symbol": "",
                    "iri": "http://flybase.org/reports/FBrf0217751",
                    "types": [
                        "Entity",
                        "Individual",
                        "pub"
                    ],
                    "short_form": "FBrf0217751",
                    "label": "Marella et al., 2012, Neuron 73(5): 941--950"
                },
                "FlyBase": "",
                "PubMed": "22405204",
                "DOI": "10.1016/j.neuron.2011.12.032"
            }
        },
        {
            "synonym": {
                "scope": "has_exact_synonym",
                "label": "dopaminergic VUM neuron",
                "type": ""
            },
            "pub": {
                "core": {
                    "symbol": "",
                    "iri": "http://flybase.org/reports/Unattributed",
                    "types": [
                        "Entity",
                        "Individual",
                        "pub"
                    ],
                    "short_form": "Unattributed",
                    "label": ""
                },
                "FlyBase": "",
                "PubMed": "",
                "DOI": ""
            }
        }
    ],
    "def_pubs": [
        {
            "core": {
                "symbol": "",
                "iri": "http://flybase.org/reports/FBrf0217751",
                "types": [
                    "Entity",
                    "Individual",
                    "pub"
                ],
                "short_form": "FBrf0217751",
                "label": "Marella et al., 2012, Neuron 73(5): 941--950"
            },
            "FlyBase": "",
            "PubMed": "22405204",
            "DOI": "10.1016/j.neuron.2011.12.032"
        }
    ]
}